Trends: A Brief introduction to microRNA

Why study microRNA?

MicroRNAs are important regulators in post-transcriptional gene regulation. The active secretion of miRNA into circulation during diseases onset renders it a promising biomarker candidate.

In the last 10 years, a growing number of studies and reviews have associated presence of various miRNAs with progression of
cancer. miRNA expression fingerprints had been shown to correlate with clinical and biological characteristics of tumors, including tissue type, differentiation, aggression and response to therapy. There have been ~12000 in the last 9 years and virtually every publication involves quantification of microRNA.


 

 

Presenting to you - eleven pathways, which MiRXES had co-developed with Clarivate Analytics – market leader in pharmaceutical and biotechnology intelligence. All 352 highly curated and wet-lab validated miRNA are from MiRXES ID3EAL Cancer microRNA Knowledge panel and are strongly associated with various cancer types and known to regulate up to hundreds of key onco- and tumour suppressor genes and pathways. 

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 Reference Guide 

co-developed with Clarivate Analytics 

 derived from MiRXES Knowledge Panel

 microRNA 
 
Pathway 

11 vital pathways involved in Oncology 

Mapped out using 352 highly curated miRNA

p53

signalling

01 

FAS

signalling cascade

02

EGFR

signalling cascade

03

VEGF

family signalling

01 

WNT

signalling pathway

05

06

Regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases 

07

Regulation of immune cell differentiation by Notch signalling

08

Differentiation of natural regulatory T cells

09

Inhibitory PD-1 signalling in T cells

10

Macrophage-induced immunosuppression in the tumour microenvironment

11

Macrophage and dendritic cell phenotype shift in cancer

MiRXES ID3EAL miRNA qPCR Starter kit is also available

learn more about MiRXES ID3EAL miRNA qPCR Starter kit
 

 
 
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 MiRXES redefines miRNA Quantification 

Get the best-in-class

performance

MiRXES miRNA solutions had found its way to bring you unparalleled specificity. MiRXES assays are based on an unique 3-specific priming strategy, and no random priming is involved. These assays are also designed using in-house proprietary algorithm to boosted its sensitivity. All assays have been wet-lab validated, in accordance to MiQE guidelines and when presented together, all these factors sets MiRXES apart from assays available in the market.

It is a known challenge that the quantification of microRNA are extremely small and shares high homology, hence hampering accurate quantification.         

Watch: MiRXES patented technology
using 3-specific priming strategy

For initial starters to microRNA research, MiRXES ID3EAL miRNA qPCR Starter kit is also available. The starter kit is an all-inclusive kit that consists of reagents required to perform 20 cDNA reactions, 100qPCR reactions, and two validated primer sets of choice*.

miRNA Starter kit
product info here